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After the timeskip, Buggy's appearance has changed greatly. While in the confines of Impel Down, Buggy's long hair is tied into just one ponytail. It was revealed in an SBS question that the blue tassels coming from the sides of Buggy's hat are his actual hair in the shape of two ponytails. He wore beanies rather than a captain's hat and he lacked the captain's coat. He wore a different outfit in each flashback but dressed similarly to how he does now, usually seen in striped T-shirts (or collared shirts), white gloves, baggy pants, pointed shoes, and donning a sash. Roger's ship, he looked mostly the same the only notable differences were his shorter hair and smaller stature. ![]() While in the manga his scarf and sash are orange just like many other components of his attire, his pants are light-brown and the epaulets of his coat are simply gold, in the anime he was given a much more bright color scheme, with a purple scarf, green sash, light-green pants, and green epaulets.ĭuring the Whitebeard War Saga, after escaping from Impel Down, Buggy modified his striped prisoner's outfit with salvaged Marine uniform pieces to recreate the effects of a pirate captain: a coat and a tricorn that had the symbols crossed out. On his head he has an orange hat with his jolly roger on it, over a bandanna with the same pattern of his shirt. ![]() Hanging from his shoulders there is an orange, fur-lined captain's coat. In his pirate captain attire, he dons a striped white and red shirt with short sleeves, white gloves reminiscent of the ones worn by clowns, a sash around his waist like many other pirates, and a pair of loose pants reaching to his calves, just above a pair of striped socks and pointy shoes. In the Impel Down saga, he has crossbones again going down his forehead to below his eyes, two pink lines pointing up, and red lipstick. He also has green eyeliner and green lipstick, with a curvy line going down both sides of his face. After that (when his crew meets Ace), he has two green dots on both sides of his head and four big green dots on the rim of his hat, which still has the jolly roger on it. First, a green star appears in the middle of the forehead, two half circles appear beneath the eyes, and there is a straight line on the middle of his chin. However, in later episodes after the Loguetown arc his look changes. ![]() Buggy's face is always covered with make up, just like a clown, and the motifs change from time to time: in his first appearance he had crossbones going down his face forming an X he also had two blue lines near both of his eyes, red lipstick and his jolly roger on his hat. ![]() The basic steps involved in developing a new drug from scratch haven’t changed much. It could be a few years yet before the first drugs designed with the help of AI hit the market, but the technology is set to shake up the pharma industry, from the earliest stages of drug design to the final approval process. “But the ultimate validation needs to be done in the lab.” Still, AI is already changing how drugs are being made. It’s already doing a lot of the steps that we used to do by hand,” says Luisa Salter-Cid, chief scientific officer at Pioneering Medicines, part of the startup incubator Flagship Pioneering in Cambridge, Massachusetts. There are a lot of AI companies making claims they can’t back up, says Prakash: “If somebody tells you they can perfectly predict which drug molecule can get through the gut or not get broken up by the liver, things like that, they probably also have land to sell you on Mars.”Īnd the technology is not a panacea: experiments on cells and tissues in the lab and tests in humans-the slowest and most expensive parts of the development process-cannot be cut out entirely. Yet it is still early days for AI drug discovery. “We’re going to see huge transformation in this industry over the next five years.” We’re seeing this uptick in activity and investment because increasing automation in the pharmaceutical industry has started to produce enough chemical and biological data to train good machine-learning models, explains Sean McClain, founder and CEO of Absci, a firm based in Vancouver, Washington, that uses AI to search through billions of potential drug designs. “If somebody tells you they can perfectly predict which drug molecule can get through the gut … they probably also have land to sell you on Mars.” Adityo Prakash, CEO of Verseon All told, around two dozen drugs (and counting) that were developed with the assistance of AI are now in or entering clinical trials. Last year Exscientia opened a new research center in Vienna in February, Insilico Medicine, a drug discovery firm based in Hong Kong, opened a large new lab in Abu Dhabi. Now, new labs are being built around the world. By predicting how potential drugs might behave in the body and discarding dead-end compounds before they leave the computer, machine-learning models can cut down on the need for painstaking lab work.Īnd there is always a need for new drugs, says Adityo Prakash, CEO of the California-based drug company Verseon: “There are still too many diseases we can’t treat or can only treat with three-mile-long lists of side effects.” The vision is to use AI to make drug discovery faster and cheaper. Today, on average, it takes more than 10 years and billions of dollars to develop a new drug. ![]() There are now hundreds of startups exploring the use of machine learning in the pharmaceutical industry, says Nathan Benaich at Air Street Capital, a VC firm that invests in biotech and life sciences companies: “Early signs were exciting enough to attract big money.” “If we were using a traditional approach, we couldn’t have scaled this fast,” Hopkins says.Įxscientia isn’t alone. The company is on the way to submitting two more. Since 2021, two drugs that Exscientia developed (or co-developed with other pharma companies) have started the process. The first drugs designed with the help of AI are now in clinical trials, the rigorous tests done on human volunteers to see if a treatment is safe-and really works-before regulators clear them for widespread use. This could in turn yield even more options to sift through when looking for a match. In addition to pairing patients up with existing drugs, Exscientia is using machine learning to design new ones. The company is set on overhauling the entire drug development pipeline. Selecting the right drug is just half the problem that Exscientia wants to solve. ![]() My goal is to make every customer satisfied with their order, and you can order a customized T-shirt / customized with the picture you like with CUSTOM ORDER. International Shipping should take 1-3 weeks to be delivered after being shipping * PayPal is a safe, fast and easy online payment. Do not use bleach or detergents with stain lifters. ![]() PRODUCT FEATURES David Rose Wild Aloof Rebel Sweatshirt For Unisex USA Sizing Chart :ĢXL = 32″ body length x 26″ chest Care Instructions: They’ve spent practically every minute of the off-season together, in a blissful little bubble floating back and forth between Manhattan and Toronto and even Schitt’s Creek whenever they get the urge. 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Feel free to choose the type most suitable to your creative needs.Ĭopic Sketch: our global bestseller with an oval ergonomic design and color coded caps, comes with the flexible super brush nib and a medium broad nib. Copic Sketch and Classic are compatible with the Copic Air Brush System. What differs is the overall design, colors available, the type of nib used and the amount of ink in the markers. All our markers are made in Japan and evaluated against the highest quality standards, they are all refillable with Copic Ink and feature replaceable premium quality nibs. If you do not allow these cookies, you will experience less targeted advertising.There are 3 types of Copic markers*: Ciao, Sketch and Classic. They do not store directly personal information, but are based on uniquely identifying your browser and internet device. They may be set through our site by our advertising partners, to build a profile of your interests and to show you relevant adverts on other sites. 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YOU are all I need to support my development in these early months of my life. Those researchers tell us that when you learn to read and understand the cues that I give you (like crying or wriggling) and you respond appropriately by giving me what I need in that moment, you are doing more for my brain development than any structured activity or fancy shop bought gadget will ever achieve.Īs I feel loved and understood by you, I begin to better understand who I am myself and how the world works. When you understand me, you help me to make sense of the world around me. Remember that loud noises, bright lights or even the sudden temperature change of getting undressed can overwhelm me at this stage. I need your help to pick me up, rock me, sing to me, softly stroke my face and make me feel that it will all be ok. I feel a lot and often my feelings get too big for me to manage aloneĮven though I am small, I feel a lot and often my feelings get too big for me to manage alone. I like it best when you just walk your fingers up my leg at the end or even nicer, rub my foot in circles at the end. But please don’t tickle me at the end, it can be over stimulating for me and feel uncomfortable. I love when you do this every single day! Also, that you count and play with my toes doing “this little piggy went to market”. This means you bring your nose in to touch mine, moving slowly so as not to frighten me and touching me gently, then rubbing your nose side to side with mine a couple of times. Your touch is magical to me and it helps me to develop and feel safe and organised. In fact, some researchers suggest that if they took an MRI scan of my brain and one of your brain, that lying our two scans on top of each other would show a mirror image…isn’t that exciting? I am born neurologically wired to connect and attach to you. Because when I learn that I can count on you to meet my needs and respond to my cries, I learn to trust and I learn that I am deserving of love. Your love is how I acquire my first developmental milestone, trust. ![]() The magical connection between my mummy and me You are as special to them as they are to you. We now know that it is impossible to “spoil” a new born baby and that the more we respond to their cries in those early developmental months, the less needy and more resilient they will grow to be.Īs soon as your baby is born they know you and can pick you out of a crowd. The impact that a parent’s love and attention has on a baby’s development is researched and undeniable. Bonding with baby during this special time is key to supporting their development. ![]() If I imagine that you are parsing a command-line string where order is important, I would stick with IList if I were you. It will therefore behave the same way regardless of the CommaSeparate() method's return type.Īs someone else pointed out, the FXCop rule warns against using List, not IList the question you linked to is asking why FXCop doesn't recommend using IList in place of List, which is another matter. Regardless of the runtime type of the object returned, consider the behavior when the static reference is IList or ICollection: When you call GetEnumerator() (perhaps implicitly in a foreach loop), you're going to call the same method and get the same object regardless of the static type of the reference. If you need the method to return, by contract, a type whose contract requires a certain order, then you should express that in the method's signature by returning the more specific type. For example, if you return the Values collection of a SortedDictionary, the objects will be in the the order defined by the dictionary's comparer. The objects will be in the order specified by the object returned. The ICollection interface doesn't specify anything about an order. In the case of an API contract, to indicate order, which of the following is correct: IEnumerable Grob(string s) It is critical that the order of items be maintained.Ĭonceptually, i require a contract that indicates an "ordered" set of string tuples. This begs the wider question: Does an ICollection even have an order?Ĭonceptually, imagine i want to parse a command line string. Is there a ways to access items of a collection in order? Unfortunately, my internal implementation constructs an array which i can be cast to return IList or ICollection, but not as a Collection. Implements IEnumerable(Of Box).Following the rules that a public APIs should never return a list, i'm blinding converting all code that returned lists, to return ICollection instead: public IList CommaSeparate(String value) ![]() Public Function GetEnumerator() As IEnumerator(Of Box) _ ' the non-generic IEnumerable method is explicitly implemented. ' be used with the non-generic IEnumerator. ' The generic enumerator obtained from IEnumerator by GetEnumerator can also ![]() Public Class BoxCollection : Implements ICollection(Of Box) Public Overrides Function GetHashCode() As Integer ![]() Public Overrides Function Equals(ByVal obj As Object) As Boolean In this article, I am going to give you a brief Introduction to Collections in C.Please read our previous article where we discussed the Advantages and Disadvantages of Arrays in C with Examples. Public Overloads Function Equals(ByVal other As Box) As Boolean Implements IEquatable(Of Box).Equals Back to: C.NET Tutorials For Beginners and Professionals Introduction to Collections in C. Public Sub New(ByVal h As Integer, ByVal l As Integer, ByVal w As Integer) Public Class Box : Implements IEquatable(Of Box) using System īoxCollection bxList = new BoxCollection() Ĭonsole.WriteLine("Contains ", bx.Height.ToString(), bx.Length.ToString(), bx.Width.ToString(), bx.GetHashCode().ToString()) This example also implements an IEnumerator interface for the BoxCollection class so that the collection can be enumerated. The BoxCollection class also provides an overload of the Contains method that takes a specified Equalit圜omparer object, such as BoxSameDimensions and BoxSameVol classes in the example. This method is used by the Add method so that each Box added to the collection has a unique set of dimensions. The BoxCollection class implements the Contains method to use the default equality to determine whether a Box is in the collection. The Box class implements the IEquatable interface to define the default equality as the dimensions being the same. Equality can be defined as all dimensions being the same or the volume being the same. Each Box has height, length, and width properties, which are used to define equality. The following example implements the ICollection interface to create a collection of custom Box objects named BoxCollection. “There's incredible innovation going on right now and we just don't talk about it enough.” A second flatbed truck served as a “power source,” he said. The missiles were removed from the ally’s ship and then mounted on the back of a flatbed truck. The Boeing-made Harpoon anti-ship missiles used in the strike were given to the Ukrainians by a U.S. A "vendor" trained the Ukrainians, the official said. was part of a coalition team that did the training, a U.S. “We got them off the ship, put them on some flatbed trucks, put the Harpoons, the modules on the flatbed truck, and then a different flatbed truck for the power source, connected a cable between it, figured out was exportable, brought the Ukrainians to train on it over Memorial Day weekend, in our country, over Memorial Day weekend, and the next week two Russian ships were sunk with those Harpoons,” he said. ![]() Instead, she said, he meant that the weekend the Ukrainians received training is called Memorial Day in the United States. “brought the Ukrainians to train on over Memorial Day weekend, in our country, over Memorial Day weekend.”Ī spokesperson for LaPlante said the undersecretary did not mean that the Ukrainians received training in the United States. That key detail of the strike and a few others were disclosed Wednesday by Bill LaPlante, defense undersecretary for acquisition and sustainment, during a conference panel hosted by Defense News near the Pentagon. Ukrainian forces who sank a Russian warship with Harpoon missiles in June were trained by the United States, the Pentagon’s top weapons buyer said. Clarification: A Pentagon spokesperson said Bill LaPlante did not mean to say that Ukrainians were trained in the United States. ![]() “Sound - and in particular sound healing meditations using Tibetan singing bowls, gongs, and quartz crystal singing bowls - can be extremely calming,” says Tamara Goldsby, a research psychologist at the University of California, San Diego. For over 40,000 years Australian aboriginal tribes used the didgeridoo as a sound healing instrument according to Psychology Today. Other ancient rituals using sound originated in Tibet or Himalaya, using singing bowls for spiritual ceremonies. Sound is embedded in the ancient roots of cultures and tribes around the world and has a specific relationship with meditation and healing. Sometimes participants may stay in a seated position on comfortable cushions during a session. Attendees at such events will be asked to lie down on a yoga mat and ‘bathe’ in the sounds, which don’t follow a particular melody. ![]() This is achieved through sounds created by a number of different instruments played by instructors or sound therapists. Global Wellness Economy Monitor report, October 2018īut, what is a sound bath and what is it that makes them so special?Įssentially, a sound bath is a meditation class that aims to guide you into a deep, meditative state. Perhaps this is a sign that it’s only a matter of time for it to be part of popular culture. Like her or not, trend-starter Kim Kardashian celebrated the arrival of her forth baby with a gong bath last year. It’s no longer a niche, new-age hype but seems to becoming the new norm. They have received a 285% rise from 2018–2019. Instead of booking into a yoga class or massage, more and more people are now attending sound baths. It’s been named one of 2020’s biggest wellness trend by Condé Nast Traveller. There’s also been a huge increase in demand for sound meditations, such as gong baths. The industry grew from a $3.7 trillion to a $4.2 trillion market in three years, nearly twice as fast as global economic growth (3.6 percent annually). Perhaps this is why the wellness sector is booming. ” With more and more of the world’s population suffering from stress-related conditions, it’s clear that we must all work to reduce stress. The World Health Organisation (WHO) has classified stress as the, “health epidemic of the 21st century. Sound Meditations may be the solution to many of the stress-related issues of modern life. This is our bodies telling us we need more ‘off’ time. Likewise, noise and light pollution, which are exacerbated by daily life, fuel stresses that previous generations didn’t experience.Ī state of high alertness caused by stress can lead to health problems, anxiety, sleeping issues and even depression according the National Institute of Mental Health. Measurement company Zenith, who conducted this research expects this to grow to over four hours by 2021.Ĭonnectivity is part of modern life, as is social media and the news churn amplified by push-notifications. Recent data shows that American adults spent about three hours and 30 minutes a day using the internet on their phones. Work is the most common source of stress in daily life, followed by money, finance and family issues. ![]() A study revealed that two thirds of Brits are “overwhelmed” by life pressures. It does not store any personal data.There’s no denying our lives are becoming busier and more stressful by the second. 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Necessary cookies are absolutely essential for the website to function properly. ![]() ![]() Because, like the rival mob boss says in The Godfather about Don Corleone: “He makes money for his friends.” Even Fox News said in open court that Carlson shouldn’t be taken seriously, but he is allowed to carry on anyway. The grievances are aided and abetted by wide-eyed Tucker Carlson, the prime-time evening host on Fox. Right wing and far right media are stirring things up, part of their overall business plan. The annual State Of The Union address is coming up, the first for President Biden, and there is the prospect of a truckers’/antivaxx/Big Lie alliance rally in DC on the day. They see the signs and are worried.Īnd this is how and where it could all get really, really bad. The US Homeland Security department has warned that a copycat truckers’ strike or worse could flare up. Now all are scrambling to shore up border controls in fright at what might spill over. Some facts: In addition to the state of Michigan: Alaska, Washington State, Montana, Minnesota, Ohio, Pennsylvania, New York State, Vermont, New Hampshire and Maine all share a border with Canada. These three countries share the same continent and this is beginning to be realised by the man and the woman on the street. It is Canada and Mexico that are the real “special relationship”. Which explains why the first trip that any new US president makes abroad is to Canada. The US trade deficit is tied to how well the country works with Canada and its southern neighbour, Mexico. There is the imagery: Confederate flags, mock-ups of the PM at the end of a noose, anti-vaxxers using the protest as a flag of convenience.Īs Brexiteers are discovering the age-old axiom that you should always trade with your nearest neighbour, Americans are starting to see that Canada and what happens there matters. ![]() And there is the sacking of the Capitol on January 6, 2020, something that had not happened since the War of 1812, when the British attacked it. There was that attempt to run a Joe Biden bus off the road during the 2020 election campaign, an action that was genuinely frightening in a country where violence is, shall we say, not uncommon. Uncivil and aggressive behaviour is escalating all over the world now, with agitators sharing tactics on social media. Meanwhile, the state of Michigan, which is losing millions because it relies on trade with Canada for machinery and auto parts to keep the state and its workers going, is begging the truckers to bring an end to all of this. Yet still supplies of petrol and food are being brought to them by sympathisers. The residents of the area in Ottawa where the honking went on all night finally got an injunction and, like proper Canadians, the truckers stopped the noise. It’s all there: the libertarians, the hipsters, folks just tired of being told what to do, all of them combined to wreak havoc on whatever and whomsoever. Highlights include protesters urinating on the National War Memorial and partying on the Tomb Of the Unknown Soldier. Out of Canada has come Freedom Convoy 2022, a protest of angry truckers against the vaccine mandates that has exploded into a crusade against those enraged by the government. So, as someone who grew up about 800 miles from Windsor, Ontario, where it is all happening – my first reaction to the chaotic scenes caused by a trucker protest is to say: “Canada? Really?” Most Americans have absolutely no idea that Canada is the second-largest country by total area in the world, that its border with the US is the longest bi-national border on earth, and that the republic’s dependence on trade with Canada in relation to electrical goods, car parts and the like is monumental.Įven in spite of the fact that, arguably, the richest guy who ever lived, Elon Musk, is Canadian and so are William Shatner, Margaret Atwood and Drake, Canada is still a blur. The WaveSurfer 3000z combines an entirely new CPU engine, an improved internal-communications bus, and up to 20 Mpoints of acquisition memory, twice that of the WaveSurfer 3000, to facilitate rapid and responsive oscilloscope operation. More Memory, More Speed, and More Insight The 100-MHz version addresses the requirements of general-purpose debugging and validation tasks, while the 1-GHz model serves users looking for the bandwidth to tackle sophisticated applications such as higher-speed serial communications test and RF signal analysis. The WaveSurfer 3000z adds a 100-MHz version that brings the powerful features of the WaveSurfer 3000 to an entry-level price, and a highly affordable, yet equally feature-loaded 1-GHz model. The WaveSurfer 3000z comes in five models with bandwidths from 100 MHz to 1 GHz and sample rates up to 4 GS/s. In addition, the new models provide more processing power and memory.Īll WaveSurfer 3000z oscilloscopes feature a large 10.1” capacitive touch screen, a vast set of debug and analysis tools, multi-instrument capabilities, feature/option upgrades, and support for a wider probe range. A digital-voltmeter option performs 4-digit voltage measurements and 5-digit frequency counting on any channel, and the protocol-analyzer option with serial trigger/decode features intuitive, color-coded waveform overlays and interactive data tables.New bandwidth models, large acquisition memory, and more software and probe options enhance utilityĬhestnut Ridge, N.Y., Ap– Teledyne LeCroy today announced the WaveSurfer 3000z oscilloscopes, which expand the existing WaveSurfer 3000 bandwidth range above and below that of earlier models, while also bolstering functionality for power-electronics testing. The function-generator option offers a standard collection of waveforms at up to 25 MHz, while the logic-analyzer option provides 16 digital channels for mixed-signal capabilities. The oscilloscope WaveSurfer 3000z can serve as a 5-in-1 instrument. The already palette of optional serial trigger/decode packages now adds an Audiobus trigger/decode package, which performs analysis and debug of the digital audio-bus standard in its I2S, LJ, RJ, and TDM variants. The WaveSurfer 3000z includes LXI-based web browsing to facilitate remote configuration and operation. The LabNotebook feature saves and/or restores oscilloscope setups and waveforms with the touch of a single button, and provides a handy tool for annotation and documentation of your work sessions. It also packs a measure and math toolset of 20 math functions for waveform insight and 24 automated parameter measurements.Ī dedicated grid eases viewing of math traces, while statistics, histicons, and trends extract revealing details from parameter measurements. With analysis features such as History mode for waveform playback, extensive triggering capabilities, and WaveScan advanced search and find, the WaveSurfer 3000z delivers detection and isolation of signal anomalies. To augment the Power Analysis software package, the WaveSurfer 3000z offers an active-probe interface that supports Teledyne LeCroy’s power-focused HVFO103 high-voltage, fiber optically-isolated probe, RP4030 power-rail probe, CP03xA current probe, and HVD3000/3000A high-voltage differential probes. The WaveSurfer 3000z’s display update rate of 130,000 waveforms/s makes it easy to identify anomalies during power analysis. Now available for the WaveSurfer 3000z, the Power Analysis software package performs detailed analysis of line power, control loops, and system/device power performance. The 10.1” capacitive touch screen combines with Teledyne LeCroy’s MAUI user interface to give users a better look at waveforms and deeper insight into signal abnormalities. The WaveSurfer 3000z combines an new CPU engine, an improved internal-communications bus, and up toĢ0 Mpoints of acquisition memory, twice that of the WaveSurfer 3000. WaveSurfer 3000z oscilloscopes incorporate power analysis software tools and are compatible with a variety of probes dedicated to power electronics and conversion circuit testing.These new oscilloscopes with 4 analog inputs are also distinguished by their memory capacity of up to 20 Mpoints.The WaveSurfer 3000z range includes five models, with a capacitive touch screen of 10.1″, offering bandwidths of 100 MHz, 200 MHz, 350 MHz, 500 MHz and 1 GHz and sampling rates up to 4 GS/s.Teledyne LeCroy completes the WaveSurfer 3000 oscilloscope range with models from the WaveSurfer 3000z series. |
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